Development of a DNA aptamer targeting IDO1 with anti-tumor effects
Summary: Immune checkpoint blockade has become an effective approach to reverse the immune tolerance of tumor cells.Indoleamine 2,3-dioxygenase 1 (IDO1) is frequently upregulated in many types of cancers and contributes to the establishment of an immunosuppressive cancer microenvironment, which has been thought Rug Large to be a potential target fo